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Doublecortin Antibody
Goat Polyclonal
600-101-MH8S
600-101-MH8
25 µg
100 µg
Liquid (sterile filtered)
Liquid (sterile filtered)
WB, IHC, IF
Human, Mouse, Rat
Goat
Shipping info:
$50.00 to US & $70.00 to Canada for most products. Final costs are calculated at checkout.
Product Details
Anti-Doublecortin (GOAT) Antibody - 600-101-MH8
Goat Anti-Doublecortin Antibody, Lissencephalin-X, Doublecortex, Doublin, Lis-X, DBCN, LISX, Doublecortex Lissencephaly X-Linked (Doublecortin), Neuronal Migration Protein Doublecortin, SCLH, XLIS, DC
Goat
Polyclonal
IgG
Target Details
DCX - View All DCX Products
Human, Mouse, Rat
Conjugated Peptide
Anti-Doublecortin antibody was prepared from whole goat serum produced by repeated immunizations with a synthetic peptide corresponding to a near C-terminal portion of human doublecortin conjugated to Keyhole Limpet Hemocyanin (KLH).
This affinity purified antibody is directed against human Neuronal migration protein doublecortin. This product was affinity purified from monospecific antiserum by immunoaffinity purification. Blast analysis the immunogen sequence shows 100% identity with rat.
Application Details
IF, IHC, WB
Anti-Doublecortin Antibody has been tested in WB, IF, and IHC. Expect bands ~40.6 kDa in western blot using appropriate lysates. Positive control used: PND2-6 brain cells in western blot; PND1 in immunofluorescence; and mouse dentate gyrus for immunohistochemistry.
Formulation
1.29 mg/ml by UV absorbance at 280 nm
0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
0.01% (w/v) Sodium Azide
None
Shipping & Handling
Dry Ice
Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
Expiration date is one (1) year from date of receipt.
DCX (Neuronal Migration Protein Doublecortin) is a microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. It may act by competing with the putative neuronal protein kinase DCLK1 in binding to a target protein. In that way, it may participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. Doublecortin may be part with PAFAH1B1/LIS-1 of overlapping, but distinct, signaling pathways that promote neuronal migration. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, cognitive disability, subcortical band heterotopia ("double cortex" syndrome) in females and lissencephaly ("smooth brain" syndrome) in males. Anti-Neuronal Migration Protein Doublecortin Antibody is useful for researcher interested in developmental biology, cytoskeletal signaling, neuroscience, and protein kinase binding.
This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information. All products of animal origin manufactured by Rockland Immunochemicals are derived from starting materials of North American origin. Collection was performed in United States Department of Agriculture (USDA) inspected facilities and all materials have been inspected and certified to be free of disease and suitable for exportation. All properties listed are typical characteristics and are not specifications. All suggestions and data are offered in good faith but without guarantee as conditions and methods of use of our products are beyond our control. All claims must be made within 30 days following the date of delivery. The prospective user must determine the suitability of our materials before adopting them on a commercial scale. Suggested uses of our products are not recommendations to use our products in violation of any patent or as a license under any patent of Rockland Immunochemicals, Inc. If you require a commercial license to use this material and do not have one, then return this material, unopened to: Rockland Inc., P.O. BOX 5199, Limerick, Pennsylvania, USA.