Strategies for Oligonucleotide Drug Delivery and Detection

Join this webinar to hear from leading experts, Aimee L. Edinger, VMD/PhD and Carl A. Ascoli, PhD, who will discuss cutting-edge advancements in the field of oligonucleotide drug delivery and detection. Learn how to overcome the hurdle of inefficient endosomal escape for oligonucleotide therapeutics with an approach that uses a synthetic sphingolipid analog to enhance the activity of antisense oligonucleotides and small interfering RNAs without causing endosomal permeability. In addition, you'll be introduced to a revolutionary panel of universal detection reagents designed to detect specific chemical modifications for the collection of ADME analytical data.

Key topics include:

• Inhibition of endocytic recycling and lysosomal fusion
• Methods to enhance the activity of antisense oligonucleotides and small interfering RNAs by up to 100x
• Challenges that hinder oligonucleotide therapeutic drug development
• Analytical tools for assessing drug performance and safety

Presenters:
Aimee L. Edinger, VMD/PhD | Dept. of Developmental and Cell Biology, UC Irvine
Carl Ascoli, PhD | Chief Science Officer, Rockland