Localization and Quantification of Oligonucleotide Therapeutic Drugs

This introductory poster presents ModDetect, Rockland’s platform of validated monoclonal antibodies that recognize key chemical modifications in oligonucleotide therapeutics (ONTs), including phosphorothioate (PS), 2’-O-methoxy-ethyl (MOE), and 2’-O-methyl (OMe). Designed for use across diverse assay types, ModDetect provides an orthogonal alternative to LC-MS/MS and ligand binding assays by enabling direct localization and quantification of ONTs in lysates and biofluids. Explore how this powerful tool supports drug development pipelines by improving analytical confidence in ADMET and regulatory studies.