More than two decades ago, David Baltimore and Ranjan Sen discovered a DNA binding factor that was found to be ubiquitously present and conserved in several biochemical pathways. Twenty-five years later, more than 44,000 articles have been published on NF-κB and its partners. To mark the 25th anniversary of the discovery of NF-κB we look at the antibodies we produced against NF-κB, its phosphorylated forms, subunits, inhibitors and NLS sites using new technologies. At Rockland, our philosophy is to continuously reinvent ourselves and deliver the best antibodies and tools to target NF-κB and its related proteins.