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PDE12 protein-GST fusion
009-001-S85S
009-001-S85
20 µg
50 µg
Liquid (sterile filtered)
Liquid (sterile filtered)
Human
Sf9 cells
This product is discontinued
Product Details
PDE12 recombinant protein-GST fusion protein - 009-001-S85
2'-PDE,2',5'-phosphodiesterase 12, Mitochondrial deadenylase
Human
Sf9 cells
Recombinant Protein
Target Details
PDE12
Recombinant full-length human PDE12 was expressed by baculovirus in Sf9 insect cells using an N-Terminal Glutathione-S-Transferase fusion protein. The purity was determined to be >90% by densitometry.
?term=NM_177966 - Gene ID
Application Details
PDE12 Protein is stored in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. PDE12 Protein is suitable for use in PDE Assay. Expect a band approximately ~100kDa on specific lysates or tissues. Specific conditions for reactivity should be optimized by the end user.
Formulation
0.1 µg/µL
See application note.
Shipping & Handling
Dry Ice
Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Expiration date is one (1) year from date of receipt.
PDE12 is 2', 5'-phosphodiesterase 12 protein that belongs to the CCR4/nocturin family. PDE12 cleaves the 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates. Triphosphorylated oligoadenylates, which are referred to as 2-5A, modulates in the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs) (1). Suppression of PDE12 induces reduction of viral replication in Hela cells, thus counteracting the antiviral pathway probably by inhibiting the 2-5A system. PDE12 Protein is ideal for investigators involved in Signaling Proteins, Cellular Proteins, Cardiovascular Disease, Inflammation, and Phosphodiesterase research.
This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information. All products of animal origin manufactured by Rockland Immunochemicals are derived from starting materials of North American origin. Collection was performed in United States Department of Agriculture (USDA) inspected facilities and all materials have been inspected and certified to be free of disease and suitable for exportation. All properties listed are typical characteristics and are not specifications. All suggestions and data are offered in good faith but without guarantee as conditions and methods of use of our products are beyond our control. All claims must be made within 30 days following the date of delivery. The prospective user must determine the suitability of our materials before adopting them on a commercial scale. Suggested uses of our products are not recommendations to use our products in violation of any patent or as a license under any patent of Rockland Immunochemicals, Inc. If you require a commercial license to use this material and do not have one, then return this material, unopened to: Rockland Inc., P.O. BOX 5199, Limerick, Pennsylvania, USA.
