Troponin I (Cardiac) Phospho S43 Antibody
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Datasheet

Troponin I (Cardiac) Phospho S43 Antibody

Rabbit Polyclonal

600-401-X34
100 µL
Liquid (sterile filtered)
WB
Mouse, Rat
Rabbit
$475.00 /Per Item
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Product Details

Anti-Troponin I (cardiac) pS43 (RABBIT) Antibody - 600-401-X34
Troponin I cardiac muscle, Cardiac troponin I
Rabbit
Polyclonal
IgG

Target Details

Tnni3  - View All Tnni3 Products
Mouse, Rat
Phosphorylation
Conjugated Peptide
Anti-Phospho-Ser43 Troponin (cardiac) Antibody was produced in rabbits by repeated immunizations with a synthetic phospho-peptide corresponding to amino acid residues surrounding Ser43 of mouse cardiac troponin I conjugated to KLH.
Anti-Phospho-Ser43 Troponin (cardiac) Antibody is directed against Troponin protein phosphorylated at S43. The antibody was prepared from monospecific antiserum by immunoaffinity chromatography using phospho peptide coupled to agarose beads followed by solid phase adsorption(s) against non-phospho peptide and non-specific peptide to remove any unwanted reactivities. Assay by immunoelectrophoresis resulted in a single precipitin arc against anti-Rabbit Serum. This antibody is specific for phosphorylated Troponin. Minimal reactivity occurs against non-phosphorylated Troponin. Reactivity against Troponin occurs from mouse sources. However, reactivity is also expected against bovine, canine, human, non-human primate, sheep, Xenopus, and zebrafish based on 100% sequence homology.
P48787 - UniProtKB
NP_033432.1 - NCBI Protein
21954 - Gene ID

Application Details

WB
Anti-Phospho-Ser43 Troponin (cardiac) Antibody has been tested by Western Blots and is specific for the ~25 kDa cardiac troponin I protein phosphorylated at Ser 43. Immunolabeling is greatly decreased with lambda-phosphatase treatment. Specific conditions for reactivity should be optimized by the end user.

Formulation

Titrated value sufficient to run approximately 10 mini blots.
0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5
None
0.1 mg/ml Bovine Serum Albumin (BSA) - IgG and Protease free, 50% (v/v) Glycerol

Shipping & Handling

Dry Ice
Store vial at -20° C prior to opening in undiluted aliquots. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature.
Expiration date is one (1) year from date of receipt.
Troponin I (TnI) is 1 of 3 subunits, along with troponin C (TnC) and Troponin T (TnT) of troponin complex found in cardiac (cTnI) and fast skeletal (fsTnI) muscle. Protein kinase C-mediated phosphorylation of cardiac myofilament proteins has been shown to depress the actomyosin interaction and may be important during heart failure. Studies indicate that phosphorylation of Ser43 and Ser45 of cardiac troponin I plays a substantial role in the PKC-mediated depression. Troponin I pS43 Antibody is ideal for researchers interested in cancer research.

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This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information. All products of animal origin manufactured by Rockland Immunochemicals are derived from starting materials of North American origin. Collection was performed in United States Department of Agriculture (USDA) inspected facilities and all materials have been inspected and certified to be free of disease and suitable for exportation. All properties listed are typical characteristics and are not specifications. All suggestions and data are offered in good faith but without guarantee as conditions and methods of use of our products are beyond our control. All claims must be made within 30 days following the date of delivery. The prospective user must determine the suitability of our materials before adopting them on a commercial scale. Suggested uses of our products are not recommendations to use our products in violation of any patent or as a license under any patent of Rockland Immunochemicals, Inc. If you require a commercial license to use this material and do not have one, then return this material, unopened to: Rockland Inc., P.O. BOX 5199, Limerick, Pennsylvania, USA.

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