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TLR3 Antibody
Mouse Monoclonal 40C1285.6 IgG1 kappa
200-301-I24
100 µg
Liquid
WB, IHC, IF, FC, IP
Human
Mouse
Shipping info:
$50.00 to US & $70.00 to Canada for most products. Final costs are calculated at checkout.
Product Details
Anti-TLR3 (MOUSE) Monoclonal Antibody - 200-301-I24
Toll-like receptor 3, CD283
Mouse
Monoclonal
IgG1
Target Details
TLR3 - View All TLR3 Products
Human
Conjugated Peptide
TLR3 Antibody was produced in mice prepared by repeated immunizations with a peptide corresponding to internal amino acid sequences in the human protein TLR3.
Anti-TLR3 Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with Anti-TLR3 from dog, human and mouse based on 100% homology with the immunizing sequence. Cross-reactivity with Anti-TLR3 from other sources has not been determined.
Application Details
FC, IF, IHC, IP, WB
Anti-TLR3 Antibody is tested for use in WB, Flow, Flow-IC, ICC/IF, IHC, IHC-P, IP, and Bioactivity. Expect a band approximately 120kDa on specific lysates. Specific conditions for reactivity should be optimized by the end user.
Formulation
1.0 mg/ml by UV absorbance at 280 nm
0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
0.05% (w/v) Sodium Azide
0.05% BSA
Shipping & Handling
Dry Ice
Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
Expiration date is one (1) year from date of receipt.
Anti-TLR3 Antibody detects human TLR3. The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules and could constitute an important and unrecognized component of innate immunity in humans. The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition. TLRs characterized so far activate the MyD88/interleukin-1 receptor-associated kinase (IRAK) signaling pathway. Ten human homologs of TLRs (TLR1-10) have been described. TLR3 cDNA codes for a protein with approximate molecular weight of 120 kDa. TLR3 has a restricted expression pattern being expressed in dendritic cells (DC). TLR3 mRNA expression was detected by in situ hybridization in DC and lymph nodes . The expression of TLR3 in a single cell type may indicate a specific role for this molecule in a restricted setting. Anti-TLR3 Antibody is ideal for investigators involved in cytokines and growth factor research.
This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information. All products of animal origin manufactured by Rockland Immunochemicals are derived from starting materials of North American origin. Collection was performed in United States Department of Agriculture (USDA) inspected facilities and all materials have been inspected and certified to be free of disease and suitable for exportation. All properties listed are typical characteristics and are not specifications. All suggestions and data are offered in good faith but without guarantee as conditions and methods of use of our products are beyond our control. All claims must be made within 30 days following the date of delivery. The prospective user must determine the suitability of our materials before adopting them on a commercial scale. Suggested uses of our products are not recommendations to use our products in violation of any patent or as a license under any patent of Rockland Immunochemicals, Inc. If you require a commercial license to use this material and do not have one, then return this material, unopened to: Rockland Inc., P.O. BOX 5199, Limerick, Pennsylvania, USA.
