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SOCS1 Antibody
Rabbit Polyclonal
600-401-H18
100 µg
Liquid (sterile filtered)
WB, ELISA
Human, Mouse, Rat
Rabbit
Shipping info:
$50.00 to US & $70.00 to Canada for most products. Final costs are calculated at checkout.
Product Details
Anti-SOCS1 (RABBIT) Antibody - 600-401-H18
SSI1, TIP3
Rabbit
Polyclonal
IgG
Target Details
SOCS1 - View All SOCS1 Products
Human, Mouse, Rat
Conjugated Peptide
SOCS1 Antibody was produced from whole rabbit serum prepared by repeated immunizations with a peptide near the c-terminus of human SOCS1.
Anti-SOCS1 Antibody was affinity purified from monospecific antiserum by immunoaffinity purification. A BLAST analysis was used to suggest cross-reactivity with SOCS1 with Human, Mouse and Rat based on 100% homology with the immunizing sequence. Cross-reactivity with SOCS1 from other sources has not been determined.
Application Details
ELISA, WB
Anti-SOCS1 Antibody is tested for use in ELISA and WB. Expect a band approximately ~23.5 kDa on specific lysates. Specific conditions for reactivity should be optimized by the end user.
Formulation
1.0 mg/mL by UV absorbance at 280 nm
0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
0.02% (w/v) Sodium Azide
None
Shipping & Handling
Dry Ice
Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
Expiration date is one (1) year from date of receipt.
SOCS1 antibody detects human SOCS1. The Suppressor of cytokine signaling (SOCS) and cytokine-inducible SH2 proteins are a family of intracellular proteins which regulate the immune cell responses to cytokines. SOCS1 acts to suppress dendritic cell (DC) as well as T cell hyperactivation following cytokine signaling by inhibiting JAK tyrosine kinase, a kinase necessary for type I and II cytokine receptors to initiate signaling, by directly binding to the catalytic domain of the kinase. SOCS1 also possesses E3 ubiquitin protein ligase activity that results in the polyubiquitination of its target proteins and subsequent degradation by the proteosome. It is through this method that SOCS1 negatively regulates signaling by Toll-like receptors TLR2 and TLR4 by mediating the degradation of the TLR signaling adaptor protein TIRAP. Anti-SOCS1 antibodies are ideal for investigators involved in cytokines and growth factors research.
