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PI 3 Kinase p85 alpha phospho Y607 Antibody
Rabbit Polyclonal
600-401-MR1
100 µg
Liquid (sterile filtered)
ELISA, IHC, Dot Blot
Human
Rabbit
Shipping info:
$50.00 to US & $70.00 to Canada for most products. Final costs are calculated at checkout.
Product Details
Anti-PI 3 Kinase p85 alpha pY607 (RABBIT) Antibody - 600-401-MR1
Rabbit Anti-Phosphoinositide-3-Kinase Regulatory Subunit 1, Phosphatidylinositol 3-Kinase 85 KDa Regulatory Subunit Alpha, Phosphoinositide-3-Kinase, Regulatory Subunit 1 (Alpha), Phosphatidylinositol 3-Kinase Regulatory Subunit Alpha, Phosphoinositide-3-Kinase Regulatory Subunit Alpha, PtdIns-3-Kinase Regulatory Subunit Alpha, PI3K Regulatory Subunit Alpha, PI3-Kinase Subunit P85-Alpha, GRB1, Phosphatidylinositol 3-Kinase, Regulatory Subunit, Polypeptide 1 (P85 Alpha), Phosphatidylinositol 3-Kinase-Associated P-85 Alpha, PtdIns-3-Kinase Regulatory Subunit P85-Alpha, PI3-Kinase Regulatory Subunit Alpha, P85-ALPHA, IMD36, AGM7, P85
Rabbit
Polyclonal
IgG
Target Details
PIK3R1 - View All PIK3R1 Products
Human
Phosphorylation
Conjugated Peptide
Anti-PI 3 Kinase p85 alpha pY607 antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to a C-Terminal portion of human PIK3R1 conjugated to Keyhole Limpet Hemocyanin (KLH).
This affinity purified antibody is directed against the phosphorylated form of human PIK3R1 protein at the pY607 residue. This product was affinity purified from monospecific antiserum by immunoaffinity purification. The product was affinity purified from monospecific antiserum by immunoaffinity purification. Antiserum was first purified against the phosphorylated form of the immunizing peptide. The resultant affinity purified antibody was then cross adsorbed against the non-phosphorylated form of the immunizing peptide. Reactivity with non-phosphorylated human PIK3R1 Y607 is minimal by ELISA and dot blot. Reactivity against homologues from other sources is not known. A BLAST analysis was used to suggest reactivity with the antigen based on 100% homology with the immunizing sequence to human, mouse, and rat.
Application Details
Dot Blot, ELISA, IHC
Anti-PI 3 Kinase p85 alpha pY607 Antibody has been tested in ELISA, DB, and IHC. Expect a band at ~83.6kDa in western blot using appropriate tissues or lysates. Positive control used: Human Brain Tissue in Immunohistochemistry.
Formulation
0.80 mg/ml by UV absorbance at 280 nm
0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
0.01% (w/v) Sodium Azide
None
Shipping & Handling
Dry Ice
Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
Expiration date is one (1) year from date of receipt.
PI 3-Kinases (phosphoinositide 3-kinases, PI 3-Ks) are responsible for coordinating a diverse range of cell functions, including proliferation and survival, and plays an important role in the metabolic actions of insulin, a mutation in this gene has been associated with insulin resistance. It binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. It is necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Phosphatidylinositol 3-kinase plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling. Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement. Anti-PI 3 Kinase p85 alpha pY607 Antibody is useful for researchers interested in studying Short Syndrome, Agammaglobulinemia 7 Autosomal Recessive, Gastric Cancer Research, and Interleukin-7 Signaling.
This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information. All products of animal origin manufactured by Rockland Immunochemicals are derived from starting materials of North American origin. Collection was performed in United States Department of Agriculture (USDA) inspected facilities and all materials have been inspected and certified to be free of disease and suitable for exportation. All properties listed are typical characteristics and are not specifications. All suggestions and data are offered in good faith but without guarantee as conditions and methods of use of our products are beyond our control. All claims must be made within 30 days following the date of delivery. The prospective user must determine the suitability of our materials before adopting them on a commercial scale. Suggested uses of our products are not recommendations to use our products in violation of any patent or as a license under any patent of Rockland Immunochemicals, Inc. If you require a commercial license to use this material and do not have one, then return this material, unopened to: Rockland Inc., P.O. BOX 5199, Limerick, Pennsylvania, USA.