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Datasheet

PHC3 Antibody

Rabbit Polyclonal

600-401-DM0
100 µg
Liquid (sterile filtered)
WB, ELISA
Human, Mouse, Rat
Rabbit
$475.00 /Per Item
Out of stock
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$50.00 to US & $70.00 to Canada for most products. Final costs are calculated at checkout.

Product Details

Anti-PHC3 (RABBIT) Antibody - 600-401-DM0
PHC3 Antibody, EDR3, HPH3, EDR3, PH3, Polyhomeotic-like protein 3, Early development regulatory protein 3, hPH3
Rabbit
Polyclonal
IgG

Target Details

PHC3  - View All PHC3 Products
Human, Mouse, Rat
Conjugated Peptide
Anti-PHC3 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 19 amino acid peptide near the N-terminus of human PHC3.
Anti-PHC3 antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. PHC3 antibody is human, mouse and rat specific. At least six isoforms of PHC3 are known to exist.
Q8NDX5 - UniProtKB
NP_079223 - NCBI Protein
80012 - Gene ID

Application Details

ELISA, WB
Anti-PHC3 Antibody has been tested for use in ELISA and Western Blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band at approximately 106 kDa in Western Blots of specific cell lysates and tissues.

Formulation

1 mg/mL by UV absorbance at 280 nm
0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
0.02% (w/v) Sodium Azide
None

Shipping & Handling

Dry Ice
Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
Expiration date is one (1) year from date of receipt.
Polycomb group (PcG) proteins assemble into multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes throughout development (1). PHC3 (Polyhomeotic-like protein 3), also known as Early development regulatory protein 3, is a 983 amino acid nuclear protein that is a component of the PcG multiprotein PRC1 complex (2). PRC1 complex acts via chromatin remodeling and modification of histones. PHC3 contains 1 FCS-type zinc finger and SAM (sterile alpha motif) domain (2-3). PHC 3 has been regarded as a candidate tumor suppressor of osteosarcoma (4).

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This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information. All products of animal origin manufactured by Rockland Immunochemicals are derived from starting materials of North American origin. Collection was performed in United States Department of Agriculture (USDA) inspected facilities and all materials have been inspected and certified to be free of disease and suitable for exportation. All properties listed are typical characteristics and are not specifications. All suggestions and data are offered in good faith but without guarantee as conditions and methods of use of our products are beyond our control. All claims must be made within 30 days following the date of delivery. The prospective user must determine the suitability of our materials before adopting them on a commercial scale. Suggested uses of our products are not recommendations to use our products in violation of any patent or as a license under any patent of Rockland Immunochemicals, Inc. If you require a commercial license to use this material and do not have one, then return this material, unopened to: Rockland Inc., P.O. BOX 5199, Limerick, Pennsylvania, USA.