Datasheet is currently unavailable. Try again or CONTACT US
NMDA R2C Antibody
Rabbit Polyclonal
1 References
600-401-D94
10 µg
Lyophilized
WB, IP
Human, Mouse, Rat
Rabbit
Shipping info:
$50.00 to US & $70.00 to Canada for most products. Final costs are calculated at checkout.
Product Details
Anti-NMDA R2C (RABBIT) Antibody - 600-401-D94
Glutamate [NMDA] receptor subunit epsilon-3, N-methyl D-aspartate receptor subtype 2C, NMDAR2C, NR2C
Rabbit
Polyclonal
IgG
Target Details
Grin2c - View All Grin2c Products
Human, Mouse, Rat
Recombinant Protein
Anti-NMDA R2C Antibody was produced by repeated immunizations with a fusion proteins from the N-terminal region of the NR2C subunit.
Anti-NMDA R2C antibody is directed against NMDA R2C protein. The antibody was affinity purified from monospecific antiserum by immunoaffinity purification. Immunolabeling is blocked by preadsorption of antibody with the immunogen that was used to generate the antibody. Reactivity is expected from human and mouse. Cross reactivity from other species has not been determined.
Q00961 - UniProtKB
Application Details
IP, WB
Anti-NMDA R2C Antibody is tested for use in Western Blotting and Immunoprecipitation and suitable for IHC and IF. Specific conditions for reactivity should be optimized by the end user. Expect a band of approximately 140 kDa in size corresponding to the NR2C subunit of the NMDA receptor. This antibody also labels the approximately 180 kDa NR2A and NR2B subunits of the NMDA receptor.
Formulation
50µL
Neutral PBS
Shipping & Handling
Ambient
Store vial at 4° C prior to restoration. For extended storage aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. Dilute only prior to immediate use.
Expiration date is one (1) year from date of receipt.
NMDA R2C Antibody detects NMDA R2C protein. The ion channels activated by glutamate that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR). The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer’s, epilepsy and ischemic neuronal cell death. The NMDA receptor is also one of the principal molecular targets for alcohol in the CNS. The NMDAR is also potentiated by protein phosphorylation. The rat NMDAR1 (NR1) was the first subunit of the NMDAR to be cloned. The NR1 protein can form NMDA activated channels when expressed in Xenopus oocytes but the currents in such channels are much smaller than those seen in situ. Channels with more physiological characteristics are produced when the NR1 subunit is combined with one or more of the NMDAR2 (NR2 A-D) subunits. The NR2C subunit of the receptor is thought to influence the NMDAR conductance level. Anti-NMDA R2C Antibody is ideal for investigators involved in Neuroscience, Signal Transduction, and Cell Signaling Research.
Yoshikawa M et al. (2022). Free d-Amino Acids in Salivary Gland in Rat. Biology.
Applications
WB, IB, PCA
This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information. All products of animal origin manufactured by Rockland Immunochemicals are derived from starting materials of North American origin. Collection was performed in United States Department of Agriculture (USDA) inspected facilities and all materials have been inspected and certified to be free of disease and suitable for exportation. All properties listed are typical characteristics and are not specifications. All suggestions and data are offered in good faith but without guarantee as conditions and methods of use of our products are beyond our control. All claims must be made within 30 days following the date of delivery. The prospective user must determine the suitability of our materials before adopting them on a commercial scale. Suggested uses of our products are not recommendations to use our products in violation of any patent or as a license under any patent of Rockland Immunochemicals, Inc. If you require a commercial license to use this material and do not have one, then return this material, unopened to: Rockland Inc., P.O. BOX 5199, Limerick, Pennsylvania, USA.
