Datasheet is currently unavailable. Try again or CONTACT US
NMDA NR2B Subunit phospho Y1336 Antibody
Rabbit Polyclonal
612-401-C88
100 µL
Liquid
WB, IHC
Mouse, Rat
Rabbit
Shipping info:
$50.00 to US & $70.00 to Canada for most products. Final costs are calculated at checkout.
Product Details
Anti-NMDA NR2B Subunit pY1336 (RABBIT) Antibody - 612-401-C88
Glutamate [NMDA] receptor subunit epsilon-2, N-methyl D-aspartate receptor subtype 2B, NMDAR2B, NR2B, Grin2b
Rabbit
Polyclonal
IgG
Target Details
Grin2b - View All Grin2b Products
Mouse, Rat
Phosphorylation
Conjugated Peptide
Anti-NMDA NR2B Subunit pY1336 Antibody was produced by repeated immunizations with a synthetic phospho-peptide corresponding to amino acid residues surrounding Tyr1336.
Anti-NMDA NR2B Subunit pY1336 antibody is directed against rat NMDA 2B receptor protein. The antibody was affinity purified from monospecific antiserum by immunoaffinity purification. Anti-NMDA NR2B Subunit pY1336 antibody is specific for the phosphorylated protein. Immunolabeling of the NMDAR NR2B subunit band is blocked by lambda-phosphatase treatment. The antibody has been directly tested for reactivity in Western blots rat tissue. Reactivity is expected from the following species based on 100% sequence homology: human, mouse and non-human primates.
Q00960 - UniProtKB
NP_036706.1 - NCBI Protein
Application Details
IHC, WB
Anti-NMDA NR2B Subunit pY1336 (Rabbit) antibody is tested for use in Western Blotting and IHC. Specific conditions for reactivity should be optimized by the end user. Expect a band of approximately 180 kDa in size corresponding to NMDAR NR2B subunit protein phosphorylated at Tyr1336 in the appropriate cell lysate or extract.
Formulation
0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5
0.1 mg/ml Bovine Serum Albumin (BSA) - IgG and Protease free, 50% (v/v) Glycerol
Shipping & Handling
Dry Ice
Store vial at -20° C prior to opening. This product is stable at 4° C as an undiluted liquid. For extended storage, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Dilute only prior to immediate use.
Expiration date is one (1) year from date of receipt.
NMDA 2B pY1336 antibody detects NMDA 2B receptor protein. The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer’s, epilepsy and ischemic neuronal cell death. The rat NMDAR1 (NR1) was the first subunit of the NMDAR to be cloned. The NR1 protein can form NMDA activated channels when expressed in Xenopus oocytes but the currents in such channels are much smaller than those seen in situ. Channels with more physiological characteristics are produced when the NR1 subunit is combined with one or more of the NMDAR2 (NR2 A-D) subunits. Phosphorylation of Tyr1336 is thought to potentiate NMDA receptor-dependent influx of calcium and ischemia may also increase the phosphorylation of this site. NMDA NR2B Subunit pY1336 antibody is ideal for investigators involved in Cell Signaling, Neuroscience, and Signal Transduction research.
This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information. All products of animal origin manufactured by Rockland Immunochemicals are derived from starting materials of North American origin. Collection was performed in United States Department of Agriculture (USDA) inspected facilities and all materials have been inspected and certified to be free of disease and suitable for exportation. All properties listed are typical characteristics and are not specifications. All suggestions and data are offered in good faith but without guarantee as conditions and methods of use of our products are beyond our control. All claims must be made within 30 days following the date of delivery. The prospective user must determine the suitability of our materials before adopting them on a commercial scale. Suggested uses of our products are not recommendations to use our products in violation of any patent or as a license under any patent of Rockland Immunochemicals, Inc. If you require a commercial license to use this material and do not have one, then return this material, unopened to: Rockland Inc., P.O. BOX 5199, Limerick, Pennsylvania, USA.
