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Neuromodulin phospho S41 Antibody
Rabbit Polyclonal
612-401-D59
100 µL
Liquid
WB
Mouse, Rat
Rabbit
Shipping info:
$50.00 to US & $70.00 to Canada for most products. Final costs are calculated at checkout.
Product Details
Anti-Neuromodulin (GAP43) pS41 (RABBIT) Antibody - 612-401-D59
Neuromodulin, Axonal membrane protein GAP-43, GAP43, Growth-associated protein 43, Protein F1, Neural phosphoprotein B-50, pp46
Rabbit
Polyclonal
IgG
Target Details
Gap43 - View All Gap43 Products
Mouse, Rat
Phosphorylation
Conjugated Peptide
Anti-Neuromodulin Antibody was produced by repeated immunizations with a synthetic phospho-peptide corresponding to amino acid residues surrounding Ser41 of GAP43.
Anti-GAP43 pS41 antibody was affinity purified from monospecific antiserum by immunoaffinity purification. This antibody is specific for the phosphorylated forms of the protein. Immunolabeling is completely eliminated by treatment with lambda-Ptase. Cross reactivity with GAP43 from other species has not been determined, however, the sequence of the immunogen shows 100% homology to bovine, canine, chicken, finch, human, mouse, non-human primates, Xenopus and zebra fish.
P07936 - UniProtKB
Application Details
WB
Anti-GAP43 (Rabbit) antibody is tested for use in Western Blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band of approximately 50 kDa in size corresponding to neuromodulin protein phosphorylated at Ser41 in the appropriate cell lysate or extract. In some tissues, the antibody also recognized a higher molecular weight protein that may be an aggregate or oligomer.
Formulation
0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5
0.1 mg/ml Bovine Serum Albumin (BSA) - IgG and Protease free, 50% (v/v) Glycerol
Shipping & Handling
Dry Ice
Store vial at -20° C prior to opening. This product is stable at 4° C as an undiluted liquid. For extended storage, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Dilute only prior to immediate use.
Expiration date is one (1) year from date of receipt.
Gap-43 pS41 antibody detects phosphorylated GAP43 at position S41. Gap43 is thought to have an important role in development and plasticity because it is expressed at high levels in neuronal growth cones during development and during axonal regeneration. There is also evidence from knockout animals that Gap-43 serves to amplify pathfinding signals from the growth cone. Gap-43 is thought to mediate at least some of these effects via interaction with actin. Importantly, phosphorylation at Ser41 by protein kinase C modulates the interaction of Gap-43 with actin and may also affect neurotransmitter release during forms of plasticity like LTP. Anti-Gap-43 pS41 antibody is ideal for investigators involved in Cell Signaling, Neuroscience, and Signal Transduction research.
This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information. All products of animal origin manufactured by Rockland Immunochemicals are derived from starting materials of North American origin. Collection was performed in United States Department of Agriculture (USDA) inspected facilities and all materials have been inspected and certified to be free of disease and suitable for exportation. All properties listed are typical characteristics and are not specifications. All suggestions and data are offered in good faith but without guarantee as conditions and methods of use of our products are beyond our control. All claims must be made within 30 days following the date of delivery. The prospective user must determine the suitability of our materials before adopting them on a commercial scale. Suggested uses of our products are not recommendations to use our products in violation of any patent or as a license under any patent of Rockland Immunochemicals, Inc. If you require a commercial license to use this material and do not have one, then return this material, unopened to: Rockland Inc., P.O. BOX 5199, Limerick, Pennsylvania, USA.