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MyD88 Antibody
Rabbit Polyclonal
1 References
600-401-955
100 µg
Liquid (sterile filtered)
WB, ELISA, IF, IP
Human, Mouse
Rabbit
Shipping info:
$50.00 to US & $70.00 to Canada for most products. Final costs are calculated at checkout.
Product Details
Anti-MyD88 (RABBIT) Antibody - 600-401-955
Myeloid differentiation marker 88 antibody, Myeloid differentiation primary response gene 88 antibody, Myeloid differentiation primary response gene antibody, Myeloid differentiation primary response protein MyD88 antibody
Rabbit
Polyclonal
IgG
Target Details
MYD88 - View All MYD88 Products
Human, Mouse
Conjugated Peptide
MYD88 Antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to a region near the carboxy terminus of human MyD88 protein.
Anti-MYD88 Antibody was affinity purified from monospecific antiserum by immunoaffinity purification. A BLAST analysis was used to suggest cross-reactivity with MYD88 with Human and Mouse based on 100% homology with the immunizing sequence. Cross-reactivity with MYD88 from other sources has not been determined.
Application Details
ELISA, IF, IP, WB
MYD88 Antibody has been tested for use in ELISA, immunofluorescence, immunoprecipitation, and western blot. This antibody is suitable for use in IHC and ICC. Expect a band approximately 33 kDa in size corresponding to MyD88 protein by western blotting in the appropriate cell lysate or extract. Specific conditions for reactivity should be optimized by the end user.
Formulation
1.0mg/mL by UV absorbance at 280 nm
0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
0.02% (w/v) Sodium Azide
None
Shipping & Handling
Dry Ice
Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
Expiration date is one (1) year from date of receipt.
MyD88 (Myeloid differentiation primary response protein). The pro-inflammatory cytokine IL-1 induced cellular response requires IL-1 receptor complex including IL-1RI and IL-1RAcP. Recently, MyD88 was identified as an adapter molecule in the IL-1 signaling pathway (1). MyD88 associates with and recruits IRAK to the IL-1 receptor complex in response to IL-1 treatment and the dominant negative form of MyD88 attenuates IL-1R-mediated NF-kB activation. MyD88 is also employed as a regulator molecule by IL-18 receptor and human Toll receptor (2,3), both members of the Toll/IL-1R family of receptors. Targeted disruption of the MyD88 gene results in loss of cellular responses to IL-1 and IL-18, and MyD88-deficient mice lack responses to the bacterial product LPS that employs Toll-like receptors 2 and 4 (TLR2 and TLR4) as the signaling receptors. MyD88 is a general adapter protein for the Toll/IL-1R family of receptors and plays an important role in the inflammatory response induced by cytokines IL-1 and IL-18 and endotoxin. The MyD88 gene is expressed in many tissues. Anti-MYD88 Antibody is ideal for investigators involved in NFkappaB, Cytokines and Growth Factor research.
Tan Y et al. (2018). Biochemical Isolation of the Myddosome from Murine Macrophages. Methods Mol Biol.
Applications
WB, IB, PCA
This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information. All products of animal origin manufactured by Rockland Immunochemicals are derived from starting materials of North American origin. Collection was performed in United States Department of Agriculture (USDA) inspected facilities and all materials have been inspected and certified to be free of disease and suitable for exportation. All properties listed are typical characteristics and are not specifications. All suggestions and data are offered in good faith but without guarantee as conditions and methods of use of our products are beyond our control. All claims must be made within 30 days following the date of delivery. The prospective user must determine the suitability of our materials before adopting them on a commercial scale. Suggested uses of our products are not recommendations to use our products in violation of any patent or as a license under any patent of Rockland Immunochemicals, Inc. If you require a commercial license to use this material and do not have one, then return this material, unopened to: Rockland Inc., P.O. BOX 5199, Limerick, Pennsylvania, USA.
