MACC1 Antibody
Anti-MACC1 Antibody - Immunohistochemistry
Anti-MACC1 Antibody - Western Blot
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Datasheet

MACC1 Antibody

Rabbit Polyclonal

600-401-C07
100 µg
Liquid (sterile filtered)
WB, ELISA, IHC, IF
Human, Mouse, Rat
Rabbit
$475.00 /Per Item
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Product Details

Anti-MACC1 (RABBIT) Antibody - 600-401-C07
MACC1 (IN), Metastasis associated in colon cancer 1, SH3 domain-containing protein 7a5
Rabbit
Polyclonal
IgG

Target Details

MACC1  - View All MACC1 Products
Human, Mouse, Rat
Conjugated Peptide
MACC1 Antibody was produced from whole rabbit serum prepared by repeated immunizations with a peptide corresponding to an internal region of human MACC1.
Anti-MACC1 Antibody was affinity purified from monospecific antiserum by immunoaffinity purification. A BLAST analysis was used to suggest cross-reactivity with MACC1 with Human, Rat and Mouse based on 100% homology with the immunizing sequence. Cross-reactivity with MACC1 from other sources has not been determined.
Q6ZN28 - UniProtKB
157502191?report=genbank&log$=protalign&blast_rank=1&RID=2TNCPCC5013 - NCBI Protein
346389 - Gene ID

Application Details

ELISA, IF, IHC, WB
Anti-MACC1 antibody has been tested in ELISA, WB, IF, and IHC. Specific conditions for reactivity should be optimized by the end user. Expect a band at ~91-96 kDa in size corresponding to MACC1 by Western blotting in the appropriate cell lysate or extract. Western Blot tested in human and mouse samples; Immunohistochemistry and Immunofluorescence in human samples. Mouse liver tissue lysate may be used as positive control.

Formulation

1.0 mg/mL by UV absorbance at 280 nm
0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
0.02% (w/v) Sodium Azide
None

Shipping & Handling

Dry Ice
Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
Expiration date is one (1) year from date of receipt.
Metastasis associated in colon cancer 1 (MACC1) is a key regulator of the hepatocyte growth factor (HGF)-HGF receptor (MET) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. MACC1 protein consists of four domains: ZU5, SH3, and two C-terminal death domains (DD). Expression of MACC1 was found significantly upregulated in malignant tissues (colon cancer of all stages as well as liver and lung metastases) compared to normal tissues or adenomas. MACC1 represents an early and crucial prognostic indicator for colon cancer metastasis that is independent of age, sex, tumor infiltration, nodal status, and lymph vessel invasion. Besides its involvement in signal transduction with the MET receptor, MACC1 also links MET signaling and apoptosis. MACC1 may also be an important therapeutic target for colorectal cancer treatment. At least two isoforms of MACC1 are known to exist. Anti-MACC1 antibody is ideal for investigators involved in cell cycle protein and cancer research.

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This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information. All products of animal origin manufactured by Rockland Immunochemicals are derived from starting materials of North American origin. Collection was performed in United States Department of Agriculture (USDA) inspected facilities and all materials have been inspected and certified to be free of disease and suitable for exportation. All properties listed are typical characteristics and are not specifications. All suggestions and data are offered in good faith but without guarantee as conditions and methods of use of our products are beyond our control. All claims must be made within 30 days following the date of delivery. The prospective user must determine the suitability of our materials before adopting them on a commercial scale. Suggested uses of our products are not recommendations to use our products in violation of any patent or as a license under any patent of Rockland Immunochemicals, Inc. If you require a commercial license to use this material and do not have one, then return this material, unopened to: Rockland Inc., P.O. BOX 5199, Limerick, Pennsylvania, USA.

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