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Kinesin-1 Antibody
Rabbit Polyclonal
100-401-E80S
100-401-E80
25 µL
100 µL
Liquid (sterile filtered)
Liquid (sterile filtered)
WB, IHC
Human
Rabbit
Shipping info:
$50.00 to US & $70.00 to Canada for most products. Final costs are calculated at checkout.
Product Details
Anti-Kinesin-1 (RABBIT) Antibody - 100-401-E80
rabbit anti-Kinesin 1 Antibody, Conventional kinesin heavy chain, Ubiquitous kinesin heavy chain, KNS, KNS1, Kinesin-1 heavy chain, UKHC, Anti-Kinesin-1 antibody, kinesin 1 antibody, kin1, kin-1, KIF5, KHC, Kinesin motor domain
Rabbit
Polyclonal
Antiserum
Target Details
KIF5B - View All KIF5B Products
Human
Recombinant Protein
Anti-Kinesin-1 was prepared from whole rabbit serum produced by repeated immunizations with a truncated kinesin-1 construct expressed in E. coli corresponding to human kinsesin-1 protein.
Anti-Kinesin-1 is directed against the human kinesin-1 protein. The product was prepared from monospecific antiserum by delipidation and defibrination. A BLAST analysis was used to suggest reactivity with human. Cross-reactivity with kinesin 1 from other sources have not been determined.
P33176 - UniProtKB
NP_004512.1 - NCBI Protein
Application Details
IHC, WB
Kinesin-1 antibody has been tested for use in western blot, and immunohistochemistry. For western blots expect a band of approximately 72 kDa in size corresponding to truncated kinesin-1 protein. Specific conditions for reactivity should be optimized by the end user.
Formulation
77 mg/mL by Refractometry
0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
0.01% (w/v) Sodium Azide
None
Shipping & Handling
Dry Ice
Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
Expiration date is one (1) year from date of receipt.
Intracellular transport is critical to cellular functions and the maintenance of its integrity (membrane renewal, vesicles trafficking, cell division, mRNA transport, etc.). Among the molecular motors that are involved in intracellular transport, three large superfamilies have been identified and well characterized these last decades – kinesins, dyneins and myosins.
Kinesins, also known as KIFs, are microtubule-dependent molecular motors that use ATP as chemical fuel to transport cargo along the microtubule network. Indeed, five major kinesin families were initially described but there are as many as 45 mammalian kinesin genes to date. In most kinesins, the motor domain is found at the N-terminus (N-type). N-type kinesins are (+) end-directed motors, i.e. they transport cargo towards the (+) end of the microtubule. In the neuronal axon, synaptic vesicle precursors, mitochondria and protein complexes are transported bi-directionally. While retrograde transport is powered by dyneins, anterograde transport is essentially powered by kinesins.
Deciphering the regulation and functions of kinesins constitutes a major challenge and will broaden our understanding of molecular motors implications in intracellular transport.
This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information. All products of animal origin manufactured by Rockland Immunochemicals are derived from starting materials of North American origin. Collection was performed in United States Department of Agriculture (USDA) inspected facilities and all materials have been inspected and certified to be free of disease and suitable for exportation. All properties listed are typical characteristics and are not specifications. All suggestions and data are offered in good faith but without guarantee as conditions and methods of use of our products are beyond our control. All claims must be made within 30 days following the date of delivery. The prospective user must determine the suitability of our materials before adopting them on a commercial scale. Suggested uses of our products are not recommendations to use our products in violation of any patent or as a license under any patent of Rockland Immunochemicals, Inc. If you require a commercial license to use this material and do not have one, then return this material, unopened to: Rockland Inc., P.O. BOX 5199, Limerick, Pennsylvania, USA.
