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HIF2 alpha Antibody
Mouse Monoclonal EP190B IgG1
209-301-F46
100 µg
Liquid (sterile filtered)
WB, IHC
Human
Mouse
Shipping info:
$50.00 to US & $70.00 to Canada for most products. Final costs are calculated at checkout.
Product Details
Anti-HIF2 alpha (MOUSE) Monoclonal Antibody - 209-301-F46
mouse anti-HIF2 alpha Antibody, mouse anti-HIF2a Antibody, ECYT4, EPAS1, HIF2alpha, HIF1 Alpha like factor, HLF, Hypoxia inducible factor 2 alpha, MOP2, PASD2, Endothelial PAS domain-containing protein 1, Basic-helix-loop-helix-PAS protein MOP2, Class E basic helix-loop-helix protein 73
Mouse
Monoclonal
IgG1
Target Details
EPAS1 - View All EPAS1 Products
Human
Recombinant Protein
HIF2 alpha Antibody was produced in mice by repeated immunizations raised against a recombinant protein corresponding to an internal region of human EPAS-1 (HIF2alpha).
Anti-HIF2α Antibody was purified by Protein G chromatography. This monoclonal antibody is specific for human HIF2α protein. A BLAST analysis was used to suggest cross-reactivity with HIF2α from human based on 100% homology with the immunizing sequence. Cross-reactivity with HIF2α from other sources has not been determined. Oxidative Stress/Cell Signaling research.
Q99814 - UniProtKB
NP_001421.2 - NCBI Protein
Application Details
IHC, WB
Anti-HIF2α Antibody was tested in WB and IHC and recommended for use in ELISA and IF microscopy. Antibody is provided in PBS pH 7.4. Specific conditions for reactivity should be optimized by the end user.
Formulation
1.0 mg/mL by UV absorbance at 280 nm
See application note.
0.09% (w/v) Sodium Azide
50% (v/v) Glycerol
Shipping & Handling
Dry Ice
Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
Expiration date is one (1) year from date of receipt.
Members of the hypoxia-inducible factor (HIF) family of transcription factors regulate the cellular response to hypoxia. HIF2-Alpha is involved in catecholamine homeostasis, vascular remodeling, physiological angiogenesis and adipogenesis. It is overexpressed in many cancerous tissues, but its exact role in tumour progression remains to be clarified. Studies suggest that in the case of non-small cell lung cancer, HIF2-Alpha actually is a promoter of tumor growth and progression in a solid tumor. Other data suggests that HIF2-Alpha is an important regulator of innate immunity, and therefore may be useful in the therapeutic target for treating inflammatory disorders and cancer.
This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information. All products of animal origin manufactured by Rockland Immunochemicals are derived from starting materials of North American origin. Collection was performed in United States Department of Agriculture (USDA) inspected facilities and all materials have been inspected and certified to be free of disease and suitable for exportation. All properties listed are typical characteristics and are not specifications. All suggestions and data are offered in good faith but without guarantee as conditions and methods of use of our products are beyond our control. All claims must be made within 30 days following the date of delivery. The prospective user must determine the suitability of our materials before adopting them on a commercial scale. Suggested uses of our products are not recommendations to use our products in violation of any patent or as a license under any patent of Rockland Immunochemicals, Inc. If you require a commercial license to use this material and do not have one, then return this material, unopened to: Rockland Inc., P.O. BOX 5199, Limerick, Pennsylvania, USA.