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GABA(A) Receptor gamma 2 Antibody
Rabbit Polyclonal
2 References
612-401-C81
100 µL
Liquid
WB, IHC, Multiplex, Other
Mouse, Rat
Rabbit
Shipping info:
$50.00 to US & $70.00 to Canada for most products. Final costs are calculated at checkout.
Product Details
Anti-GABA(A) Receptor gamma 2 (RABBIT) Antibody - 612-401-C81
Gamma-aminobutyric acid receptor subunit gamma-2, GABA(A) receptor subunit gamma-2, Gabrg2
Rabbit
Polyclonal
IgG
Target Details
Gabrg2 - View All Gabrg2 Products
Mouse, Rat
Recombinant Protein
Anti-GABA(A) Receptor gamma 2 Antibody was produced by repeated immunizations with recombinant fusion proteins from the cytoplasmic loop of the gamma 2 subunit of rat GABAA.
Anti-GABA(A) Receptor gamma 2 Antibody is directed against rat GABA(A) Receptor gamma 2. The antibody was affinity purified from monospecific antiserum by immune affinity purification. Reactivity is expected from the following species based on 100% sequence homology: bovine, chicken, canine, human, mouse, and non-human primate.
P18508 - UniProtKB
NP_899156.1 - NCBI Protein
Application Details
IHC, WB, Multiplex
Other
- View References
Anti-GABA(A) Receptor gamma 2 (Rabbit) antibody has been tested in Western Blotting and IHC. Specific conditions for reactivity should be optimized by the end user. Expect a band of 46 kDa in size corresponding to the gamma 2 subunit of the GABA(A) receptor in the appropriate cell lysate or extract.
Formulation
0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5
0.1 mg/ml Bovine Serum Albumin (BSA) - IgG and Protease free, 50% (v/v) Glycerol
Shipping & Handling
Dry Ice
Store vial at -20° C prior to opening. This product is stable at 4° C as an undiluted liquid. For extended storage, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Dilute only prior to immediate use.
Expiration date is one (1) year from date of receipt.
Anti-GABA(A) Receptor gamma 2 Antibody detects GABA(A) Receptor gamma 2. Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl− channel associated with the GABAA receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date six alphas, four betas and four gammas, plus alternative splicing variants of some of these subunits, have been identified. Injection in oocytes or mammalian cell lines of cRNA coding for alpha- and beta-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a gamma-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different alpha-subunits of the receptor. Anti-GABA(A) Receptor gamma 2 Antibody is ideal for investigators involved in Neuroscience.
Yamaura K et al. (2017). Construction of Protein-Based Biosensors Using Ligand-Directed Chemistry for Detecting Analyte Binding. Methods Enzymol.
Applications
WB, IB, PCA
Yamaura K et al. (2016). Discovery of allosteric modulators for GABA A receptors by ligand-directed chemistry. Nat Chem Biol.
Applications
WB, IB, PCA
This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information. All products of animal origin manufactured by Rockland Immunochemicals are derived from starting materials of North American origin. Collection was performed in United States Department of Agriculture (USDA) inspected facilities and all materials have been inspected and certified to be free of disease and suitable for exportation. All properties listed are typical characteristics and are not specifications. All suggestions and data are offered in good faith but without guarantee as conditions and methods of use of our products are beyond our control. All claims must be made within 30 days following the date of delivery. The prospective user must determine the suitability of our materials before adopting them on a commercial scale. Suggested uses of our products are not recommendations to use our products in violation of any patent or as a license under any patent of Rockland Immunochemicals, Inc. If you require a commercial license to use this material and do not have one, then return this material, unopened to: Rockland Inc., P.O. BOX 5199, Limerick, Pennsylvania, USA.
