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GABA(A) Receptor gamma 2 Antibody
Rabbit Polyclonal
112-401-C81
50 µL
Liquid
WB, IHC
Rat
Rabbit
Shipping info:
$50.00 to US & $70.00 to Canada for most products. Final costs are calculated at checkout.
Product Details
Anti-GABA(A) Receptor gamma 2 (RABBIT) Antibody - 112-401-C81
rabbit anti-GABA(A) Receptor gamma 2 Antibody, Gamma-aminobutyric acid receptor subunit gamma-2, GABA(A) receptor subunit gamma-2, Gabrg2
Rabbit
Polyclonal
Antiserum
Target Details
Gabrg2 - View All Gabrg2 Products
Rat
Conjugated Peptide
Anti-GABA(A) Receptor gamma 2 Antibody was produced by repeated immunizations with rat GABA(A) Receptor gamma 2- Synthetic peptide corresponding to amino acid residues specific to the gamma 2 subunit.
Anti-GABA(A) Receptor gamma 2 Antibody is directed against rat GABA(A) Receptor gamma 2. The antibody was prepared from monospecific neat serum. Expect reactivity with the following species based on 100% sequence homology: chicken, human, mouse, non-human primate, zebra fish.
P18508.1 - UniProtKB
NP_899156.1 - NCBI Protein
Application Details
IHC, WB
Anti-GABA(A) Receptor gamma 2 (Rabbit) antibody has been tested in Western Blotting and IHC. Expect a band of approximately 46kDa in size corresponding γ2-subunit of the GABAA receptor in Western blots of rat brain extracts. Specific conditions should by optimized by the end user.
Formulation
Titrated value sufficient to run approximately 10 mini blots.
Shipping & Handling
Dry Ice
Store vial at -20° C prior to opening. This product is stable at 4° C as an undiluted liquid. For extended storage, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Dilute only prior to immediate use.
Expiration date is one (1) year from date of receipt.
Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl− channel associated with the GABAA receptor (GABAA-R) sub-type. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date six αs, four βs and four γs, plus alternative splicing variants of some of these subunits, have been identified. Injection in oocytes or mammalian cell lines of cRNA coding for α- and β-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, co-expression of a γ-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different α-subunits of the receptor. Phosphorylation of β-subunits of the receptor has been shown to modulate GABAA-R function. Anti-GABA(A) Receptor gamma 2 antibody is ideal for investigators involved in Neuroscience.
This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information. All products of animal origin manufactured by Rockland Immunochemicals are derived from starting materials of North American origin. Collection was performed in United States Department of Agriculture (USDA) inspected facilities and all materials have been inspected and certified to be free of disease and suitable for exportation. All properties listed are typical characteristics and are not specifications. All suggestions and data are offered in good faith but without guarantee as conditions and methods of use of our products are beyond our control. All claims must be made within 30 days following the date of delivery. The prospective user must determine the suitability of our materials before adopting them on a commercial scale. Suggested uses of our products are not recommendations to use our products in violation of any patent or as a license under any patent of Rockland Immunochemicals, Inc. If you require a commercial license to use this material and do not have one, then return this material, unopened to: Rockland Inc., P.O. BOX 5199, Limerick, Pennsylvania, USA.
