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CREB-1 Antibody
Rabbit Polyclonal
5 References
100-401-195
100 µL
Liquid (sterile filtered)
WB, IHC, ChIP, EMSA
Human, Mouse, Rat
Rabbit
Shipping info:
$50.00 to US & $70.00 to Canada for most products. Final costs are calculated at checkout.
Product Details
Anti-CREB-1 (p43) (RABBIT) Antibody - 100-401-195
rabbit anti-CREB1 Antibody, rabbit anti-p43 antibody, Cyclic AMP-responsive element-binding protein 1, cAMP-responsive element-binding protein 1, CREB-1, CREB1, p43
Rabbit
Polyclonal
Antiserum
Target Details
CREB1 - View All CREB1 Products
Human, Mouse, Rat
Conjugated Peptide
CREB-1 (p43) peptide corresponding to a region near the N-terminus of the human protein, conjugated to Keyhole Limpet Hemocyanin (KLH).
Anti-CREB-1 was prepared from monospecific antiserum by delipidation and immunoadsorption against an E.coli lysate immobilized on agarose beads. Anti-CREB-1 (p43) may react non-specifically with other proteins. A partial cross-reactivity is observed against CREM-1 protein.
Application Details
WB
ChIP, EMSA, IHC
- View References
Anti-CREB-1 Antibody has been tested in western blot and suitable in ELISA assays. Specific conditions for reactivity should be optimized by the end user.
Formulation
2.56 mg/ml by UV absorbance at 280 nm
0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
0.01% (w/v) Sodium Azide
None
Shipping & Handling
Dry Ice
Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
Expiration date is one (1) year from date of receipt.
Anti CREB-1 Antibody recognizes CREB (cAMP response element-binding), a cellular transcription factor. CREB binds to certain DNA sequences called cAMP response elements (CRE), thereby increasing or decreasing the transcription of the downstream genes. CREB was first described in 1987 as a cAMP-responsive transcription factor regulating the somatostatin gene. Genes whose transcription is regulated by CREB include: c-fos, the neurotrophin BDNF (Brain-derived neurotrophic factor), tyrosine hydroxylase, and many neuropeptides (such as somatostatin, enkephalin, VGF, and corticotropin-releasing hormone). CREB is closely related in structure and function to CREM (cAMP response element modulator) and ATF-1 (activating transcription factor-1) proteins. CREB proteins are expressed in many animals, including humans. CREB has a well-documented role in neuronal plasticity and long-term memory formation in the brain.
Matsumura H et al. (2014). Melatonin regulates human bone sialoprotein gene transcription. J Oral Sci.
Applications
Supershift, Gel Shift, EMSA
Chen et al. (2014). IL-1β induction of MUC5AC gene expression is mediated by CREB and NF-κB and repressed by dexamethasone. Am J Physiol Lung Cell Mol Physiol.
Applications
ChIP
Wierda RJ et al. (2012). Epigenetic control of CCR5 transcript levels in immune cells and modulation by small molecules inhibitors. J Cell Mol Med.
Applications
ChIP
Philp A, Chen A, Lan D, et al. (2011). Sirtuin 1 (SIRT1) deacetylase activity is not required for mitochondrial biogenesis or peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) deacetylation following endurance exercise. J Biol Chem.
Applications
WB, IB, PCA
Gobin SJ et al. (2001). Upregulation of transcription factors controlling MHC expression in multiple sclerosis lesions. Glia.
Applications
IHC, ICC, Histology
This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information. All products of animal origin manufactured by Rockland Immunochemicals are derived from starting materials of North American origin. Collection was performed in United States Department of Agriculture (USDA) inspected facilities and all materials have been inspected and certified to be free of disease and suitable for exportation. All properties listed are typical characteristics and are not specifications. All suggestions and data are offered in good faith but without guarantee as conditions and methods of use of our products are beyond our control. All claims must be made within 30 days following the date of delivery. The prospective user must determine the suitability of our materials before adopting them on a commercial scale. Suggested uses of our products are not recommendations to use our products in violation of any patent or as a license under any patent of Rockland Immunochemicals, Inc. If you require a commercial license to use this material and do not have one, then return this material, unopened to: Rockland Inc., P.O. BOX 5199, Limerick, Pennsylvania, USA.
