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Cdk5 Antibody
Mouse Monoclonal 1H3 IgG1
4 References
200-301-163
100 µL
Liquid
WB, IHC, IF
Human, Mouse, Rat
Mouse
Shipping info:
$50.00 to US & $70.00 to Canada for most products. Final costs are calculated at checkout.
Product Details
Anti-CDK5 (MOUSE) Antibody - 200-301-163
mouse anti-cdk5 antibody, cdk, mouse anti-Cyclin-dependent kinase 5, Cell division protein kinase 5, Serine/threonine-protein kinase PSSALRE, Tau protein kinase II catalytic subunit
Mouse
Monoclonal
IgG
Target Details
Cdk5 - View All Cdk5 Products
Human, Mouse, Rat
Native Protein
Anti-CDK5 Antibody was produced by repeated immunizations with purified rat Cdk5
Anti-CDK5 Antibody is directed against rat CDK5 protein. The antibody was Protein G purified from cell culture supernatant by chromatography. The antibody shows no cross reactivity with the Cdk5 cofactor p35 or its degradation product p25. Reactivity is reported to occur from human and mouse. Cross-reactivity with CDK5 from other species has not been determined.
Q03114 - UniProtKB
Application Details
IHC, WB
IF
- View References
Anti-CDK5 (Mouse) has been tested for use in Western Blotting and is excellent for use in IHC. Specific conditions for reactivity should be optimized by the end user. Expect a band of ~28kDa in size in rat striatal lysates by Western Blotting. Anti-CDK5 antibodies also work well for immunocytochemistry using primary cultured rat neurons and for immunohistochemistry on mouse brain tissue.
Formulation
10 mini blots
0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5
0.1 mg/ml Bovine Serum Albumin (BSA) - IgG and Protease free, 50% (v/v) Glycerol
Shipping & Handling
Dry Ice
Store vial at -20° C prior to opening. This product is stable at 4° C as an undiluted liquid. For extended storage, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Dilute only prior to immediate use.
Expiration date is one (1) year from date of receipt.
CDK5 antibody recognizes the neuronal protein kinase Cdk5 which is implicated in a vast array of normal neuronal functions including regulation of neurotransmitter synthesis, the presynaptic vesicle cycle, neurotransmitter receptor trafficking and dopamine neurotransmission. At the same time Cdk5 has been implicated in a plethora of neurological and neuropsychiatric disorders including Alzheimer’s, Parkinson’s, Huntington’s, epilepsy, schizophrenia, and drug addiction. Detection of Cdk5 in normal samples as well as tissue undergoing neurodegeneration may advance studies in these areas. Moreover, this antibody may allow more accurate postmortem evaluations of Cdk5 protein expression, and thus serve as a valuable new reagent for neuropathology. Anti-CDK5 antibody is ideal for investigators involved in Cell Signaling, Neuroscience, Signal Transduction research.
Gupta P et al. (2023). Faulty Metabolism: A Potential Instigator of an Aggressive Phenotype in Cdk5-dependent Medullary Thyroid Carcinoma. bioRxiv [Preprint].
Applications
WB, IB, PCA
Thomas R et al. (2022). Integrated regulation of PKA by fast and slow neurotransmission in the nucleus accumbens controls plasticity and stress responses. J Biol Chem.
Applications
IHC, ICC, Histology
Gupta P et al. (2022). Genetic impairment of succinate metabolism disrupts bioenergetic sensing in adrenal neuroendocrine cancer. Cell Rep.
Applications
IF, Confocal Microscopy
Carter AM et al. (2021). Cdk5 drives formation of heterogeneous pancreatic neuroendocrine tumors. Oncogenesis.
Applications
WB, IB, PCA
This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information. All products of animal origin manufactured by Rockland Immunochemicals are derived from starting materials of North American origin. Collection was performed in United States Department of Agriculture (USDA) inspected facilities and all materials have been inspected and certified to be free of disease and suitable for exportation. All properties listed are typical characteristics and are not specifications. All suggestions and data are offered in good faith but without guarantee as conditions and methods of use of our products are beyond our control. All claims must be made within 30 days following the date of delivery. The prospective user must determine the suitability of our materials before adopting them on a commercial scale. Suggested uses of our products are not recommendations to use our products in violation of any patent or as a license under any patent of Rockland Immunochemicals, Inc. If you require a commercial license to use this material and do not have one, then return this material, unopened to: Rockland Inc., P.O. BOX 5199, Limerick, Pennsylvania, USA.