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Cd68 Antibody
Rabbit Polyclonal
2 References
600-401-R10
100 µg
Lyophilized
WB, IHC, IF, FC, Other
Mouse, Rat
Rabbit
Shipping info:
$50.00 to US & $70.00 to Canada for most products. Final costs are calculated at checkout.
Product Details
Anti-CD68 (RABBIT) Antibody - 600-401-R10
Macrosialin, Gp110, CD68
Rabbit
Polyclonal
IgG
Target Details
Cd68 - View All Cd68 Products
Mouse, Rat
Conjugated Peptide
CD68 affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an internal region of mouse CD68.
Anti-CD68 antibody is directed against mouse CD68 protein supplied in the buffer above with 4mg trehalose. The product was affinity purified from monospecific antiserum by immunoaffinity purification. A BLAST analysis was used to suggest reactivity with this protein from mouse and rat based on homology for the immunogen sequence. Cross reactivity with CD68 from other sources has not been determined.
P31996 - UniProtKB
Application Details
FC, IF, IHC, WB
Other
- View References
Anti-CD68 is tested for IHC-P, IHC-Fr, IF, Flow Cytometry, and Western Blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band approximately ~34.8 kDa corresponding to the appropriate cell lysate or extract.
Formulation
0.5 ug/mL by UV absorbance at 280 nm
0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3
200µL
Restore with deionized water (or equivalent)
Shipping & Handling
Ambient
Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
Expiration date is one (1) year from date of receipt.
CD68, cluster of differentiation, is a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. CD68 is a member of a family of hematopoietic mucin-like molecules that includes leukosialin/CD43 and stem cell antigen CD34. The CD68 gene is mapped to 17p13.1. Immunohistochemistry can be used to identify the presence of CD68, which is found in the cytoplasmic granules of a range of different blood cells. It is particularly useful as a marker for the various cells of the macrophage lineage, including monocytes, histiocytes, giant cells, Kupffer cells, and osteoclasts. This allows it to be used to distinguish diseases of otherwise similar appearance, such as the monocyte/macrophage and lymphoid forms of leukaemia (the latter being CD68 negative). Its presence in macrophages also makes it useful in diagnosing conditions related to proliferation or abnormality of these cells, such as malignant histiocytosis, histiocytic lymphoma, and Gaucher's disease. This antibody is suitable for researchers interested in cancer research.
Adrian M et al. (2023). Polarized microtubule remodeling transforms the morphology of reactive microglia and drives cytokine release. Nat Commun.
Applications
IHC, ICC, Histology
Abuelezz SA et al. (2017). Targeting oxidative stress, cytokines and serotonin interactions via indoleamine 2, 3 dioxygenase by coenzyme Q10: role in suppressing depressive like behavior in rats. J Neuroimmune Pharmacol.
Applications
IHC, ICC, Histology
This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information. All products of animal origin manufactured by Rockland Immunochemicals are derived from starting materials of North American origin. Collection was performed in United States Department of Agriculture (USDA) inspected facilities and all materials have been inspected and certified to be free of disease and suitable for exportation. All properties listed are typical characteristics and are not specifications. All suggestions and data are offered in good faith but without guarantee as conditions and methods of use of our products are beyond our control. All claims must be made within 30 days following the date of delivery. The prospective user must determine the suitability of our materials before adopting them on a commercial scale. Suggested uses of our products are not recommendations to use our products in violation of any patent or as a license under any patent of Rockland Immunochemicals, Inc. If you require a commercial license to use this material and do not have one, then return this material, unopened to: Rockland Inc., P.O. BOX 5199, Limerick, Pennsylvania, USA.
