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Caspase-1 Antibody
Mouse Monoclonal 14F468 IgG1 kappa
200-301-H62
100 µg
Liquid
WB, IHC, IF
Human, Mouse
Mouse
Shipping info:
$50.00 to US & $70.00 to Canada for most products. Final costs are calculated at checkout.
Product Details
Anti-Caspase-1 (MOUSE) Monoclonal Antibody - 200-301-H62
IL1BC, IL1BCE, Caspase-1, CASP-1, 3.4.22.36, Interleukin-1 beta convertase, IL-1BC, Interleukin-1 beta-converting enzyme, ICE, IL-1 beta-converting enzyme, p45, Caspase-1 subunit p20, Caspase-1 subunit p10
Mouse
Monoclonal
IgG1
Target Details
CASP1 - View All CASP1 Products
Human, Mouse
Conjugated Peptide
Caspase-1 Antibody was produced in mice by repeated immunizations with a synthetic peptide corresponding to amino acids near the c-terminus of the immunogen, human Caspase-1.
Anti-Caspase-1 Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with Anti-Caspase-1 from human and mouse based on 100% homology with the immunizing sequence. Cross-reactivity with Anti-Caspase-1 from other sources has not been determined.
Application Details
IF, IHC, WB
Anti-Caspase-1 antibody has been tested in IHC-F, IHC-P, IF, and WB. Expect a band approximately 46kDa on specific lysates. Specific conditions for reactivity should be optimized by the end user.
Formulation
1.0 mg/ml by UV absorbance at 280 nm
0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
0.05% (w/v) Sodium Azide
Shipping & Handling
Dry Ice
Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
Expiration date is one (1) year from date of receipt.
Anti-Caspase-1 detects human Caspase. Caspase proteins are a family of cysteine proteases that are key mediators of programmed cell death or apoptosis. The precursor form of all caspase proteins is composed of a prodomain, and large and small catalytic subunits. The active forms of caspases are generated by several stimuli including ligand-receptor interactions, growth factor deprivation and inhibitors of cellular functions. All known caspases require cleavage adjacent to aspartates to liberate one large and one small subunit, which associate into tetramer to form the active enzyme. Caspase-1 (ICE, IL-1b converting enzyme) is similar to the cell death gene CED-3 of Caenorhabditilis elegans and regulates multiple proinflammatory cytokines, including interleukin-1b and interferon-gamma-inducing factor. Anti-Caspase-1 antibody is ideal for investigators involved in apoptosis research.
This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information. All products of animal origin manufactured by Rockland Immunochemicals are derived from starting materials of North American origin. Collection was performed in United States Department of Agriculture (USDA) inspected facilities and all materials have been inspected and certified to be free of disease and suitable for exportation. All properties listed are typical characteristics and are not specifications. All suggestions and data are offered in good faith but without guarantee as conditions and methods of use of our products are beyond our control. All claims must be made within 30 days following the date of delivery. The prospective user must determine the suitability of our materials before adopting them on a commercial scale. Suggested uses of our products are not recommendations to use our products in violation of any patent or as a license under any patent of Rockland Immunochemicals, Inc. If you require a commercial license to use this material and do not have one, then return this material, unopened to: Rockland Inc., P.O. BOX 5199, Limerick, Pennsylvania, USA.
