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Beta-Site App-Cleaving Enzyme Antibody
Rabbit Polyclonal
2 References
200-401-984
100 µg
Liquid (sterile filtered)
WB, ELISA, IHC
Human, Mouse, Rat
Rabbit
Shipping info:
$50.00 to US & $70.00 to Canada for most products. Final costs are calculated at checkout.
Product Details
Anti-Beta-site APP Cleaving Enzyme (BACE/Asp2) (RABBIT) Antibody - 200-401-984
APP beta secretase antibody, Asp 2 antibody, ASP2 antibody, Aspartyl protease 2 antibody, BACE 1 antibody, BACE antibody, Beta secretase 1 antibody, Beta secretase antibody, Membrane-Associated Aspartic Protease 2, Beta-Site APP Cleaving Enzyme 1, Memapsin-2, Beta-Site Amyloid Beta A4 Precursor Protein-Cleaving Enzyme, Transmembrane Aspartic Proteinase Asp2
Rabbit
Polyclonal
IgG
Target Details
BACE1 - View All BACE1 Products
Human, Mouse, Rat
Conjugated Peptide
BACE Antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids near the carboxyl terminus of human BACE protein.
Anti-BACE Antibody is directed against human BACE protein. The product is affinity chromatography purified via peptide column. The antibody is human and mouse reactive. Reactivity against homologues from other sources has not been determined.
Application Details
ELISA, IHC, WB
BACE antibody has been tested for use in ELISA, western blotting, and immunohistochemistry. Human brain tissue can be used as a positive control in western blotting, and a band at approximately 70 kDa is expected. Specific conditions for reactivity should be optimized by the end user.
Formulation
1.0 mg/mL by UV absorbance at 280 nm
0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
0.02% (w/v) Sodium Azide
None
Shipping & Handling
Dry Ice
Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
Expiration date is one (1) year from date of receipt.
Accumulation of the amyloid-beta (Abeta) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer’s disease. Abeta peptide is generated by proteolytic cleavage of the beta-amyloid protein precursor (APP) at beta- and gamma-sites by two proteases. APP is first cleaved by beta-secretase, producing a soluble derivative of the protein and a membrane anchored 99-amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for gamma-secretase to generate the 4 kDa amyloid-beta peptide, which is deposited in the brains of all suffers of Alzheimer’s disease. The long-sought beta-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2). BACE/Asp2 is a novel transmembrane aspartic protease and colocalizes with APP. Anti-BACE antibody is ideal for investigators involved in Neuroscience research.
Jiang Y et al. (2022). Preclinical and randomized clinical evaluation of the p38α kinase inhibitor neflamapimod for basal forebrain cholinergic degeneration. Nat Commun.
Applications
WB, IB, PCA
Perez-Gonzalez R et al. (2020). Extracellular vesicles: where the amyloid precursor protein carboxyl-terminal fragments accumulate and amyloid-β oligomerizes. FASEB J.
Applications
WB, IB, PCA
This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information. All products of animal origin manufactured by Rockland Immunochemicals are derived from starting materials of North American origin. Collection was performed in United States Department of Agriculture (USDA) inspected facilities and all materials have been inspected and certified to be free of disease and suitable for exportation. All properties listed are typical characteristics and are not specifications. All suggestions and data are offered in good faith but without guarantee as conditions and methods of use of our products are beyond our control. All claims must be made within 30 days following the date of delivery. The prospective user must determine the suitability of our materials before adopting them on a commercial scale. Suggested uses of our products are not recommendations to use our products in violation of any patent or as a license under any patent of Rockland Immunochemicals, Inc. If you require a commercial license to use this material and do not have one, then return this material, unopened to: Rockland Inc., P.O. BOX 5199, Limerick, Pennsylvania, USA.
