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BECLIN1 Antibody
Rabbit Polyclonal
600-401-G84
100 µg
Liquid (sterile filtered)
WB, ELISA, IHC, IF
Human, Mouse, Rat
Rabbit
Shipping info:
$50.00 to US & $70.00 to Canada for most products. Final costs are calculated at checkout.
Product Details
Anti-Beclin1 (RABBIT) Antibody - 600-401-G84
GT197, BECLIN 1, BECLIN-1
Rabbit
Polyclonal
IgG
Target Details
BECN1 - View All BECN1 Products
Human, Mouse, Rat
Conjugated Peptide
Beclin-1 Antibody was produced from whole rabbit serum prepared by repeated immunizations with a peptide near the n-terminus of human Beclin-1.
Anti-Beclin-1 Antibody was affinity purified from monospecific antiserum by immunoaffinity purification. A BLAST analysis was used to suggest cross-reactivity withBeclin-1 with Human, Mouse and Rat based on 100% homology with the immunizing sequence. Cross-reactivity with Beclin-1 from other sources has not been determined.
Application Details
ELISA, IF, IHC, WB
Anti-Beclin-1 Antibody is tested for use in ELISA, Western Blot, Immunohistochemistry, and Immunofluorescence. Expect a band approximately ~51.8 kDa in western blot using positive control HEK293 whole cell lysates, mouse brain tissue for IHC and IF, or other specific lysates. Specific conditions for reactivity should be optimized by the end user.
Formulation
1 mg/mL by UV absorbance at 280 nm
0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
0.02% (w/v) Sodium Azide
None
Shipping & Handling
Wet Ice
Antibody can be stored at 4°C up to one year. Antibodies should not be exposed to prolonged high temperatures.
Expiration date is one (1) year from date of receipt.
Beclin-1 antibody detects human Beclin-1. Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. Beclin-1, a coiled-coil Bcl-2-interacting protein homologous to the yeast autophagy gene apg6, is a mammalian autophagy gene that can inhibit tumorigenesis and is expressed at reduced levels in human breast carcinoma, suggesting that defects in autophagy proteins may contribute to the development or progression of tumors. Bcl-2 can bind to Beclin-1 and inhibit Beclin-1-dependent autophagy in yeast and mammalian cells, suggesting that Bcl-2 functions as an anti-autophagy protein as well as an anti-apoptotic protein, which helps maintain autophagy at levels that are more compatible with cell survival rather than cell death. Anti-Beclin-1 antibodies are ideal for investigators involved in apoptosis and cancer research.
This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information. All products of animal origin manufactured by Rockland Immunochemicals are derived from starting materials of North American origin. Collection was performed in United States Department of Agriculture (USDA) inspected facilities and all materials have been inspected and certified to be free of disease and suitable for exportation. All properties listed are typical characteristics and are not specifications. All suggestions and data are offered in good faith but without guarantee as conditions and methods of use of our products are beyond our control. All claims must be made within 30 days following the date of delivery. The prospective user must determine the suitability of our materials before adopting them on a commercial scale. Suggested uses of our products are not recommendations to use our products in violation of any patent or as a license under any patent of Rockland Immunochemicals, Inc. If you require a commercial license to use this material and do not have one, then return this material, unopened to: Rockland Inc., P.O. BOX 5199, Limerick, Pennsylvania, USA.
