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Beclin 1 Antibody
Rabbit Polyclonal
600-401-MG4S
600-401-MG4
25 µL
100 µg
Liquid (sterile filtered)
Liquid (sterile filtered)
WB, ELISA, IHC, IF
Human, Mouse
Rabbit
Shipping info:
$50.00 to US & $70.00 to Canada for most products. Final costs are calculated at checkout.
Product Details
Anti-Beclin-1 (RABBIT) Antibody - 600-401-MG4
Rabbit Anti-Beclin-1, Beclin1 Antibody, Beclin 1 Antibody, BECN1, Coiled-Coil Myosin-Like BCL2-Interacting Protein, Beclin 1 Autophagy Related, Beclin 1 (Coiled-Coil, Moesin-Like BCL2 Interacting Protein), ATG6 Autophagy Related 6 Homolog, Protein GT197, VPS30, GT197
Rabbit
Polyclonal
IgG
Target Details
BECN1 - View All BECN1 Products
Human, Mouse
Conjugated Peptide
Anti-BECLIN1 antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to a near N-terminal portion of human Beclin-1 conjugated to Keyhole Limpet Hemocyanin (KLH).
This affinity purified antibody is directed against human Beclin-1. This product was affinity purified from monospecific antiserum by immunoaffinity purification. A BLAST analysis was used to suggest cross-reactivity with the antigen based on 100% homology with the immunizing sequence to human, mouse, rat, bovine, pongo abelii, and wild boar and 92% to Gallus gallus.
Application Details
ELISA, IF, IHC, WB
Anti-BECLIN-1 Antibody has been tested in ELISA, WB, IF, and IHC. Expect a band at ~51.8kDa in western blot using appropriate lysates. Positive control used: U251-MG in WB; HeLa in IF; Human spleen and colon cancer tissues in IHC.
Formulation
1.0 mg/ml by UV absorbance at 280 nm
0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
0.01% (w/v) Sodium Azide
None
Shipping & Handling
Dry Ice
Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
Expiration date is one (1) year from date of receipt.
BECLIN1 belongs to the beclin family. Beclin 1 plays a central role in autophagy, a catabolic process of degradation induced by starvation. Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which mediates vesicle-trafficking processes. This protein is thought to play a role in multiple cellular processes, including tumorigenesis, neurodegeneration and apoptosis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus. Localized in the Golgi apparatus > trans-Golgi network membrane. Interaction with ATG14 promotes translocation to autophagosomes. Expressed in dendrites and cell bodies of cerebellar Purkinje cells. Anti-Beclin-1 Antibody is useful for researchers interested in Cancer Research including Cervix Carcinoma and Breast Cancer.
This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information. All products of animal origin manufactured by Rockland Immunochemicals are derived from starting materials of North American origin. Collection was performed in United States Department of Agriculture (USDA) inspected facilities and all materials have been inspected and certified to be free of disease and suitable for exportation. All properties listed are typical characteristics and are not specifications. All suggestions and data are offered in good faith but without guarantee as conditions and methods of use of our products are beyond our control. All claims must be made within 30 days following the date of delivery. The prospective user must determine the suitability of our materials before adopting them on a commercial scale. Suggested uses of our products are not recommendations to use our products in violation of any patent or as a license under any patent of Rockland Immunochemicals, Inc. If you require a commercial license to use this material and do not have one, then return this material, unopened to: Rockland Inc., P.O. BOX 5199, Limerick, Pennsylvania, USA.
