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BAG4 Antibody
Rabbit Polyclonal
200-401-ES1
100 µg
Liquid (sterile filtered)
WB, ELISA, IHC, IF
Human, Mouse, Rat
Rabbit
Shipping info:
$50.00 to US & $70.00 to Canada for most products. Final costs are calculated at checkout.
Product Details
Anti-BAG4 (RABBIT) Antibody - 200-401-ES1
BAG-4, SODD, SODD Antibody, BAG family molecular chaperone regulator 4, Bcl-2-associated athanogene 4
Rabbit
Polyclonal
IgG
Target Details
BAG4 - View All BAG4 Products
Human, Mouse, Rat
Conjugated Peptide
Anti-BAG4 antibody was prepared from whole rabbit serum produced by repeated immunizations with a peptide corresponding to amino acids near the N-terminus of human BAG4.
Anti-BAG4 Antibody is purified by DEAE purification methods. Cross reactivity with BAG4 from other sources has not been determined.
Application Details
ELISA, IF, IHC, WB
Anti-BAG4 Antibody has been tested for use in ELISA, Western blotting, immunocytochemistry and immunofluorescence. Specific conditions for reactivity should be optimized by the end user. Expect a band at approximately 50 kDa in Western blots of specific cell lysates and tissues.
Formulation
1 mg/mL by UV absorbance at 280 nm
0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
0.02% (w/v) Sodium Azide
None
Shipping & Handling
Dry Ice
Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
Expiration date is one (1) year from date of receipt.
Apoptosis is a process induced by specific cytokines, including TNF and Fas ligand, which belong to the TNF family. These cytokines exert their effects through their death domain-containing receptors, TNF-R1 and Fas. Recently, several additional death receptors have been identified, including DR3, DR4, DR5, and DR6. The apoptotic signal is transmitted by adapter molecules containing death domains that interact with the death domains of these receptors. A novel TNF-R1 interacting protein, named BAG4 (also known as silencer of death domains), was recently identified. BAG4 associates with the death domain of TNF-R1, preventing its constitutive activation. Upon TNF treatment, BAG4 is released, allowing adapter molecules such as TRADD to recruit to the active TNF-R1 complex, thereby activating TNF signaling pathways. Additionally, BAG4 interacts with DR3. BAG4 is ubiquitously expressed across various human tissues and cell lines.
This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information. All products of animal origin manufactured by Rockland Immunochemicals are derived from starting materials of North American origin. Collection was performed in United States Department of Agriculture (USDA) inspected facilities and all materials have been inspected and certified to be free of disease and suitable for exportation. All properties listed are typical characteristics and are not specifications. All suggestions and data are offered in good faith but without guarantee as conditions and methods of use of our products are beyond our control. All claims must be made within 30 days following the date of delivery. The prospective user must determine the suitability of our materials before adopting them on a commercial scale. Suggested uses of our products are not recommendations to use our products in violation of any patent or as a license under any patent of Rockland Immunochemicals, Inc. If you require a commercial license to use this material and do not have one, then return this material, unopened to: Rockland Inc., P.O. BOX 5199, Limerick, Pennsylvania, USA.