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Anti-MEN1 Antibody
Chicken Polyclonal
200-901-MJ8S
200-901-MJ8
25 µL
100 µg
Liquid (sterile filtered)
Liquid (sterile filtered)
WB, IHC
Human
Chicken
Shipping info:
$50.00 to US & $70.00 to Canada for most products. Final costs are calculated at checkout.
Product Details
Anti-MEN1 (CHICKEN) Antibody - 200-901-MJ8
Chicken Anti-Menin1 Antibody, Menin 1, Menin, SCG2, Multiple Endocrine Neoplasia I, MEAI
Chicken
Polyclonal
IgY
Target Details
MEN1 - View All MEN1 Products
Human
Conjugated Peptide
Anti-Menin1 antibody was prepared from eggs of chickens laid after repeated immunizations with a synthetic peptide corresponding to a C-Terminal portion of human MEN1 conjugated to Keyhole Limpet Hemocyanin (KLH).
This affinity purified antibody is directed against human Menin1. This product is an IgY fraction antibody purified from monospecific chicken egg yolks by a multi-step process which includes selective precipitation and salt fractionation followed by extensive dialysis against the buffer stated above. Blast analysis the immunogen sequence shows 100% identity with human, mouse, rat, bovine, canine, and is highly conserved.
Application Details
IHC, WB
Anti-MEN1 Antibody has been tested in Western Blot and Immunohistochemistry. Expect a band at ~67.5, 68kDa in western blot using appropriate tissues and lysates. Anti-Menin1 should only be used for overexpressing conditions in western blot. Positive control used: Human Colon in IHC.
Formulation
1.0 mg/ml by UV absorbance at 280 nm
0.002 M Sodium Phosphate, 0.15 M Sodium Chloride, pH 7.0
0.01% (w/v) Sodium Azide
None
Shipping & Handling
Dry Ice
Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
Expiration date is one (1) year from date of receipt.
Menin is a scaffold protein that functions in histone modification and epigenetic gene regulation. It is thought to regulate several pathways and processes by altering chromatin structure through the modification of histones. Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression. May be involved in DNA repair. Anti-MEN1 Antibody is useful for researchers interested in Multiple Endocrine Neoplasia Type I, Insulinoma, Cancer Research and Epigenetic Research.
This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information. All products of animal origin manufactured by Rockland Immunochemicals are derived from starting materials of North American origin. Collection was performed in United States Department of Agriculture (USDA) inspected facilities and all materials have been inspected and certified to be free of disease and suitable for exportation. All properties listed are typical characteristics and are not specifications. All suggestions and data are offered in good faith but without guarantee as conditions and methods of use of our products are beyond our control. All claims must be made within 30 days following the date of delivery. The prospective user must determine the suitability of our materials before adopting them on a commercial scale. Suggested uses of our products are not recommendations to use our products in violation of any patent or as a license under any patent of Rockland Immunochemicals, Inc. If you require a commercial license to use this material and do not have one, then return this material, unopened to: Rockland Inc., P.O. BOX 5199, Limerick, Pennsylvania, USA.