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ABCA4 Rim Protein Antibody
Mouse Monoclonal 3F4 IgG
1 References
200-301-D05
100 µL
Liquid
WB, IHC, IF
Human, Mouse, Bovine, Xenopus
Mouse
Shipping info:
$50.00 to US & $70.00 to Canada for most products. Final costs are calculated at checkout.
Product Details
Anti-ABCA4 (Rim Protein) (MOUSE) Monoclonal Antibody - 200-301-D05
Retinal-specific ATP-binding cassette transporter, ATP-binding cassette sub-family A member 4, RIM ABC transporter
Mouse
Monoclonal
IgG
Target Details
ABCA4 - View All ABCA4 Products
Human, Mouse, Bovine, Xenopus
Native Protein
Anti-ABCA4 antibody was produced by repeated immunizations with 220-kDa (full length) partially purified native bovine disc rim protein.
Anti-ABCA4 antibody is directed against bovine ABCA4 Rim Protein. The antibody was Protein G purified from culture supernatant. Reactivity is expected against human, mouse and Xenopus. Cross-reactivity with ABCA4 from other sources has not been determined.
O35600 - UniProtKB
NP_776646.1 - NCBI Protein
Application Details
IHC, WB
IF
- View References
Anti-ABCA4 antibody has been tested by western blot and IHC and is suitable for use in ELISA. Specific conditions should be optimized by the end user. Expect a band of ~220kDa in size corresponding to ABCA4 proteins in the appropriate cell lysate or extract.
Formulation
Titrated value sufficient to run approximately 10 mini blots. by UV absorbance at 280 nm
0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5
0.1 mg/ml Bovine Serum Albumin (BSA) - IgG and Protease free, 50% (v/v) Glycerol
Shipping & Handling
Dry Ice
Store vial at -20° C prior to opening. This product is stable at 4° C as an undiluted liquid. For extended storage, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Dilute only prior to immediate use.
Expiration date is one (1) year from date of receipt.
ABCA4 antibody detects ABCA4 (ATP-binding cassette, sub-family A (ABC1), member 4, Rim Protein) a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABCA4 is a retina-specific ABC transporter with N-retinylidene-PE as a substrate. It is expressed exclusively in retina photoreceptor cells, indicating the gene product mediates transport of an essential molecule across the photoreceptor cell membrane. Mutations in this gene are found in patients diagnosed with Stargardt disease and are associated with retinitis pigmentosa-19 and age-related macular degeneration. Defects in ABCA4 are the cause of Stargardt disease type 1 (STGD1). STGD is one of the most frequent causes of macular degeneration in childhood. Defects in ABCA4 are also known to cause fundus flavimaculatus (FFM), age-related macular degeneration type 2 (ARMD2) and cone-rod dystrophy type 3 (CORD3). Anti-ABCA4 antibody is ideal for investigators involved in Cell Signaling, Neuroscience, Signal Transduction research.
Cowan CS et al. (2020). Cell types of the human retina and its organoids at single-cell resolution. Cell.
Applications
IF, Confocal Microscopy
This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information. All products of animal origin manufactured by Rockland Immunochemicals are derived from starting materials of North American origin. Collection was performed in United States Department of Agriculture (USDA) inspected facilities and all materials have been inspected and certified to be free of disease and suitable for exportation. All properties listed are typical characteristics and are not specifications. All suggestions and data are offered in good faith but without guarantee as conditions and methods of use of our products are beyond our control. All claims must be made within 30 days following the date of delivery. The prospective user must determine the suitability of our materials before adopting them on a commercial scale. Suggested uses of our products are not recommendations to use our products in violation of any patent or as a license under any patent of Rockland Immunochemicals, Inc. If you require a commercial license to use this material and do not have one, then return this material, unopened to: Rockland Inc., P.O. BOX 5199, Limerick, Pennsylvania, USA.