Human TIMP-3 ELISA Kit
KOA0315
1 Kit
ELISA
Human
156 pg/ml - 10000 pg/ml
Shipping info:
$50.00 to US & $70.00 to Canada for most products. Final costs are calculated at checkout.
Product Details
Human TIMP-3 AccuSignal ELISA Kit - KOA0315
HSMRK222, K222, K222TA2, Metalloproteinase inhibitor 3, MIG 5 protein, Protein MIG-5, SFD, TIMP metallopeptidase inhibitor 3, TIMP-3, TIMP3, TIMP3_HUMAN, Tissue inhibitor of metalloproteinases 3
ELISA Kit
156 pg/ml - 10000 pg/ml
Target Details
TIMP3 - View All TIMP3 Products
Human
Expression system for standard: NSO; Immunogen sequence: C24-P211
Natural and recombinant human TIMP-3. There is no detectable cross-reactivity with other relevant proteins.
P35625 - UniProtKB
NP_000353.1 - NCBI Protein
Application Details
ELISA
Useful in Sandwich ELISA for Quantitative Detection of Antigen. Aliquot 0.1ml per well of the 10000pg/ml, 5000pg/ml, 2500pg/ml, 1250pg/ml, 625pg/ml, 312pg/ml, 156pg/ml human TIMP-3 standard solutions into the precoated 96-well plate. Add 0.1ml of the sample diluent buffer into the control well (Zero well). Add 0.1ml of each properly diluted sample of human cell culture supernates, serum, plasma(heparin , EDTA) or saliva to each empty well. It is recommended that each human TIMP-3 standard solution and each sample be measured in duplicate.
Formulation
Heparin Sodium
1 Kit
Shipping & Handling
Wet Ice
Store vials at 4°C prior to opening. Centrifuge product if not completely clear after standing at room temperature. This product is stable for 6 months at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage freeze at -20°C or below for 12 months. Avoid cycles of freezing and thawing.
See kit insert for complete instructions.
The tissue inhibitors of metalloproteinases(TIMPs) are natural inhibitors of the matrix metalloproteinases, a group of zinc-binding endopeptidases involved in the degradation of the extracellular matrix. The TIMP3 gene is expressed in many tissues, with highest expression in the placenta. TIMP3 encodes a potent angiogenesis inhibitor and is mutated in Sorsby fundus dystrophy, a macular degenerative disease with submacular choroidal neovascularization. TIMP3 gene is mapped to 22q12.1-q13.2. Mutations in TIMP3 cause the autosomal dominant disorder Sorsby's fundus dystrophy(SFD).
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