2´-O-Methyl (2´-OMe) Panels

The Role of 2´-OMe Modifications in ASO Drug Design

2′-O-Methyl (2′-OMe) modifications are a widely used ribose sugar modification in antisense oligonucleotide therapeutics. By replacing the 2′ hydroxyl group of ribose with a methyl group, this modification enhances nuclease resistance, reduces immunogenicity, and improves binding affinity in certain sequence contexts. These properties make 2′-OMe-modified oligonucleotides more stable and less prone to degradation, supporting their use in diverse therapeutic applications.

Accurate detection and quantification of 2′-OMe-modified molecules is essential to evaluate delivery, uptake, and pharmacokinetics during drug development. Traditional detection strategies often require sequence-specific probes or complicated workflows. ModDetect™ 2′-OMe Panels overcome these challenges by providing universal detection of 2′-OMe modifications, independent of sequence or location. This flexibility enables broader applications, reduces development risk, and supports efficient candidate triage.